Synthesis of all four nucleoside-based β-amino acids as protected precursors for the synthesis of polyamide-DNA with alternating α-amino acid and nucleoside-β- …
S Bagmare, M Varada, A Banerjee, VA Kumar
Index: Bagmare, Seema; Varada, Manojkumar; Banerjee, Anjan; Kumar, Vaijayanti A. Tetrahedron, 2013 , vol. 69, # 3 p. 1210 - 1216
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Citation Number: 4
Abstract
A simple approach is described for the synthesis of all four orthogonally protected nucleoside-β-amino acids from commercially available starting materials. Synthesis of a model tetrameric DNA sequence in 5′–3'direction employing trityl strategy and glycine as α- amino acid alternating with nucleoside-β amino acids is described.
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[Nelson, Jeffrey S.; Fearon, Karen L.; Nguyen, Mark Q.; McCurdy, Sarah N.; Frediani, Jeff E.; Foy, Michael F.; Hirschbein, Bernard L. Journal of Organic Chemistry, 1997 , vol. 62, # 21 p. 7278 - 7287]
[Nelson, Jeffrey S.; Fearon, Karen L.; Nguyen, Mark Q.; McCurdy, Sarah N.; Frediani, Jeff E.; Foy, Michael F.; Hirschbein, Bernard L. Journal of Organic Chemistry, 1997 , vol. 62, # 21 p. 7278 - 7287]
[Nelson, Jeffrey S.; Fearon, Karen L.; Nguyen, Mark Q.; McCurdy, Sarah N.; Frediani, Jeff E.; Foy, Michael F.; Hirschbein, Bernard L. Journal of Organic Chemistry, 1997 , vol. 62, # 21 p. 7278 - 7287]