Xenobiotica

Metabolism of 3, 3′, 4, 4′-tetrachlorobiphenyl via sulphur-containing pathway in rat: liver-specific retention of methylsulphonyl metabolite

K HARAGUCHI*, Y Kato, Y Masuda, R Kimura

Index: Haraguchi; Kato; Masuda; Kimura Xenobiotica, 1997 , vol. 27, # 8 p. 831 - 842

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Citation Number: 16

Abstract

1. Single doses of 3, 3′, 4, 4′-tetrachlorobiphenyl (TCB) were administered intraperitoneally to the male Wistar rat for metabolism studies. 2. Seven sulphur-containing metabolites of TCB were isolated from faeces, in addition to previously reported 4-hydroxy-3, 3′, 4′, 5-tetrachlorobiphenyl and 5-hydroxy-TCB. Major sulphur-containing metabolites were 5-and 6-methylthio-TCBs, and 6-methylsulphonyl-3-methylthio-3′, 4, 4′- ...