Synthesis and antitumor activity of 9-acyloxyellipticines.

…, M OHASHI, T HASHIYAMA, K TSUJIHARA

Index: Harada, Naoyuki; Ozaki, Kunihiko; Oda, Kouji; Nakanishi, Noriyuki; Ohashi, Motoaki; Hashiyama, Tomiki; Tsujihara, Kenji Chemical and Pharmaceutical Bulletin, 1997 , vol. 45, # 7 p. 1156 - 1162

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Citation Number: 8

Abstract

Various kinds of water-soluble 9-acyloxyellipticine derivatives were synthesized in a search for compounds with potent antitumor activity. Antitumor activities against several tumors in mice (P388 leukemia, colon 26, Lewis lung carcinoma and B16 melanoma) were evaluated by using intravenous administration. Many compounds exhibited good antitumor activities; in particular, the glutarate derivative (5o) showed potent antitumor activity. This comopound ( ...