Cobalt??Mediated [2+ 2+ 2] Cycloaddition versus C H and N H Activation of Pyridones and Pyrazinones with Alkynes: An Experimental Study

C Aubert, P Betschmann, MJ Eichberg…

Index: Aubert, Corinne; Betschmann, Patrick; Eichberg, Michael J.; Gandon, Vincent; Heckrodt, Thilo J.; Lehmann, Juerg; Malacria, Max; Masjost, Birgit; Paredes, Elisa; Vollhardt, K. Peter C.; Whitener, Glenn D. Chemistry - A European Journal, 2007 , vol. 13, # 26 p. 7443 - 7465

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Citation Number: 37

Abstract

Abstract The reactivity of a range of pyridone and pyrazinone derivatives towards alkynes in the presence of cyclopentadienylcobaltbis (ethene) has been investigated. Depending on the nature of the substrates,[2+ 2+ 2]-or [2+ 2] cycloaddition, C [BOND] H, or N [BOND] H activation may occur. In the case of pyridones, the first three predominated with N-protected derivatives, whereas substrates containing N [BOND] H bonds followed an N [BOND] H ...