Novel synthesis and anti-inflammatory activities of 2, 5-disubstituted-dioxacycloalkanes

…, Y Zhang, M Zhao, C Wang, P Chan, JBH Tok…

Index: Bi, Lanrong; Zhang, Yue; Zhao, Ming; Wang, Chao; Chan, Priscilla; Tok, Jeffrey B.-H.; Peng, Shiqi Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 19 p. 5640 - 5646

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Citation Number: 19

Abstract

A novel stereospecific synthetic route to obtain a series of 2, 5-disubstituted- dioxacycloalkanes is reported. Using an in vivo inhibition assay by monitoring xylene- induced ear edema in mice, the structure–activity relationship of the dioxacycloalkane compounds was studied, and compounds possessing high anti-inflammatory activity were identified.

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