Organic letters

Synthesis of nucleoside α-thiotriphosphates via an oxathiaphospholane approach

K Misiura, D Szymanowicz, WJ Stec

Index: Misiura, Konrad; Szymanowicz, Daria; Stec, Wojciech J. Organic Letters, 2005 , vol. 7, # 11 p. 2217 - 2220

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Citation Number: 26

Abstract

Nucleoside 5'-O-(α-thiotriphosphates) were obtained in reactions of the appropriate nucleoside 5'-O-(2-thio-1, 3, 2-oxathiaphospholanes) with pyrophosphate in the presence of DBU. The presented method allows also for preparation of α-seleno congeners and corresponding α-modified diphosphates.