Benefits of a Dual Chemical and Physical Activation: Direct aza-Michael Addition of Anilines Promoted by Solvent Effect under High Pressure
…, J Maddaluno, AY Rulev, J Legros
Index: Lebleu, Thomas; Ma, Xiaolu; Maddaluno, Jacques; Legros, Julien Chemical Communications, 2014 , vol. 50, # 15 p. 1836 - 1838
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Citation Number: 4
Abstract
The unique combination of hexafluoroisopropanol (HFIP) employed as solvent and hyperbaric conditions (10–15 kbar) allows unprecedented 1, 4-addition of poor nucleophiles, such as aromatic amines, onto sluggish (cumbersome) Michael acceptors
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