Study of benzo [a] phenazine 7, 12-dioxide as selective hypoxic cytotoxin-scaffold. Identification of aerobic-antitumoral activity through DNA fragmentation

…, M de los Ángeles Aravena, C Olea-Azar…

Index: Lavaggi, Maria Laura; Cabrera, Mauricio; Aravena, Maria de los Angeles; Olea-Azar, Claudio; Lopez de Cerain, Adela; Monge, Antonio; Pachon, Gisela; Cascante, Marta; Bruno, Ana Maria; Pietrasanta, Lia I.; Gonzalez, Mercedes; Cerecetto, Hugo Bioorganic and Medicinal Chemistry, 2010 , vol. 18, # 12 p. 4433 - 4440

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Citation Number: 18

Abstract

Phenazine 5, 10-dioxides are prodrugs for antitumor therapy that undergo hypoxic-selective bioreduction to form cytotoxic species. Here we investigate the expanded system benzo [a] phenazine 7, 12-dioxides as selective hypoxic cytotoxin-scaffold. The clonogenic survival of V79 cells on aerobic and anaerobic conditions, conduct us to study antiproliferative activity on Caco-2 tumoral cells in normoxia. Electrochemical, DNA-interaction and DNA-damage ...