Site??Selective C H Borylation of Quinolines at the C8 Position Catalyzed by a Silica??Supported Phosphane–Iridium System

S Konishi, S Kawamorita, T Iwai…

Index: Konishi, Shota; Kawamorita, Soichiro; Iwai, Tomohiro; Steel, Patrick G.; Marder, Todd B.; Sawamura, Masaya Chemistry - An Asian Journal, 2014 , vol. 9, # 2 p. 434 - 438

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Citation Number: 41

Abstract

Abstract Site-selective C [BOND] H borylation of quinoline derivatives at the C8 position has been achieved by using a heterogeneous Ir catalyst system based on a silica-supported cage-type monophosphane ligand SMAP. The efficient synthesis of a corticotropin-releasing factor 1 (CRF 1) receptor antagonist based on a late-stage C [BOND] H borylation strategy demonstrates the utility of the C8 borylation reaction.