Tetrahedron Letters

A photoaffinity probe for 5-hydroxyeicosanoid dehydrogenase suitable for radioiodination

S Kim, Y Adiyaman, G Saha, WS Powell, J Rokach

Index: Kim, Seongjin; Adiyaman, Yurdanur; Saha, Goutam; Powell, William S.; Rokach, Joshua Tetrahedron Letters, 2001 , vol. 42, # 27 p. 4445 - 4448

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Citation Number: 14

Abstract

5-Hydroxy eicosanoid dehydrogenase (5h-dh) is a key enzyme responsible for the biosynthesis of 5-oxo-ETE, a potent eosinophil chemoattractant. To facilitate the identification and characterization of 5h-dh we have synthesized a photoaffinity ligand 7, designed to bind to the enzyme, and shown it to be an excellent substrate for 5h-dh. We have also synthesized a precursor 34, containing the photoaffinity label and a trimethyl tin ...