S-[2-(. omega.-Aminoalkylamino) ethyl] dihydrogen phosphorothioates and related compounds as potential antiradiation agents

JR Piper, CR Stringfellow Jr, RD Elliott…

Index: Piper,J.R. et al. Journal of Medicinal Chemistry, 1969 , vol. 12, # 2 p. 236 - 243

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Citation Number: 82

Abstract

011 known aziridine intermediates. 6 These beginnings, marked by a high level of activity, were then expanded into a series of homologs and analogs. The two routes that led to the S- 2-(w-aminoalkylamino) ethyl dihydrogen phosphorothioates 3 are outlined in Scheme I; one involved the Cortese conversion'of hydroxyethylated cqw-alkanediamines, and the other involved the Gabriel synthesis from intermediates made available by the recently developed

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