Tetrahedron letters

Synthesis of a 1-benzylpiperazin-2-one nitrone and its reaction with alkynes and alkenes

RC Bernotas, G Adams

Index: Bernotas, Ronald C.; Adams, Ginette Tetrahedron Letters, 1996 , vol. 37, # 41 p. 7339 - 7342

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Citation Number: 19

Abstract

A novel 1-benzylpiperazin-2-one nitrone has been synthesized. It readily undergoes [3+ 2] cycloadditions with alkynes and alkenes to give Δ4-isoxazolines and isoxazolidines, respectively, which can be reductively opened to 3-substituted piperazin-2-ones and 1, 3- amino alcohols.