Acta chemica scandinavica

Synthetic Routes to Nitroamino Precursors of the Food Carcinogen 2-Amino-1-methyl-6-phenyl-1H-imidazo [4, 5-b] pyridine and its 3-Methyl Isomer via Pd (0)- …

S Lindstroem, M Eriksson…

Index: Linstroem, Stefan; Eriksson, Mikael; Grivas, Spiros Acta Chemica Scandinavica, 1993 , vol. 47, # 8 p. 805 - 812

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Citation Number: 11

Abstract

Results Syntheses according to Scheme 2. The first route employs the commercially available 11 which was conveniently rearranged in one pot to the carbamate 12 by diphenyl phosphorazidate (DPPA).“Nitration of 12 followed by methylation of the resultant 13 yielded 14, basic hydrolysis of which readily afforded the nitroamine 15. The rather general cross- coupling of areneboronic acids with pyridyl bromides10 mediated by tetrakis (triphenyl- ...