Tetrahedron Letters
N6 (N-methyl-2-pyrrolidine amidine) deoxyadenosine-a new deoxynucleoside protecting group
LJ McBride, MH Caruthers
Index: McBride, L. J.; Caruthers, M. N. Tetrahedron Letters, 1983 , vol. 24, # 29 p. 2953 - 2956
Full Text: HTML
Citation Number: 52
Abstract
Abstract The synthesis and characterization of N 6 (N-methyl-2-pyrrolidine amidine) 2′- deoxyadenosine is described. This amidine is significantly more stable toward acid catalyzed depurination than N-benzoyldeoxyadenosine, is easy to prepare and can be removed rapidly and quantitatively.
Related Articles:
Fast oligonucleotide deprotection phosphoramidite chemistry for DNA synthesis
[Vu, Huynh; McCollum, Christie; Jacobson, Karen; Theisen, Pete; Vinayak, Ravi; et al. Tetrahedron Letters, 1990 , vol. 31, # 50 p. 7269 - 7272]