Further Investigations of Heterocyclic Alkylating Agents1

RK Preston, RM Peck, ER Breuninger…

Index: Preston,R.K. et al. J. Med. Chem., 1964 , vol. 7, p. 471 - 480

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Citation Number: 31

Abstract

The exceptional antitumor and mutagenic activities displa>-ed by a quinacrine derivative of a monofunctiolial nitrogen mustard, 2-methoxy-6-chloro-9-[~-(ethyl-2-chloroethyl) aminopropylamino] acridine, led to the synthesis of 50 additional mono-and difunctional analogs of acridine, quinoline, and quinazoline. The acridine nucleus was found to exert a pronounced activating influence on the nitrogen mustard moiety. On a molar basis, the “ ...