Biochemistry

Chemical models of peptide formation in translation

RE Watts, AC Forster

Index: Watts, R.Edward; Forster, Anthony C. Biochemistry, 2010 , vol. 49, # 10 p. 2177 - 2185

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Citation Number: 9

Abstract

Ribosomal incorporations of N-alkyl amino acids including proline are slower than incorporations of non-N-alkyl l-amino acids. The chemical reactivity hypothesis proposes that these results and the exclusion of nonproline N-alkyl amino acids from the genetic code are explained by intrinsic chemical reactivities of the amino acid nucleophiles. However, there is little data on the reactivities relevant to physiological conditions. Here, we use ...