Highly stereoselective transformation of (1S, 3S)-cis-1, 3-disubstituted tetrahydro-β-carbolines into (1S, 3R)-trans-1, 3-disubstituted tetrahydro-β-carbolines: an …
J Dong, TZ Meng, XX Shi, WH Zou, X Lu
Index: Dong, Jing; Meng, Tian-Zhuo; Shi, Xiao-Xin; Zou, Wen-Hui; Lu, Xia Tetrahedron Asymmetry, 2013 , vol. 24, # 15-16 p. 883 - 893
Full Text: HTML
Citation Number: 0
Abstract
Abstract An efficient and general method for the highly stereoselective transformation of (1S, 3S)-cis-1, 3-disubstituted 1, 2, 3, 4-tetrahydro-β-carbolines (THBCs) into (1S, 3R)-trans-1, 3- disubstituted THBCs is described. The method contains the following three steps: the enantiomerically pure (1S, 3S)-cis-1, 3-disubstituted THBCs 1 were first converted into (1S, 3S)-cis-1, 2, 3-trisubstituted THBCs 2 by N-1-naphthylmethylation/benzylation;(1S, 3S)-cis ...
Related Articles:
[Tetrahedron Asymmetry, , vol. 19, # 4 p. 435 - 442]
Synthesis and SAR of tetracyclic pyrroloquinolones as phosphodiesterase 5 inhibitors
[Bioorganic and Medicinal Chemistry, , vol. 12, # 6 p. 1505 - 1515]
[Letters in Organic Chemistry, , vol. 7, # 4 p. 311 - 313]
Improved synthesis of tadalafil using dimethyl carbonate and ionic liquids
[RSC Advances, , vol. 4, # 3 p. 1204 - 1211]