First total synthesis of the whole series of the antiostatins A and B

KE Knott, S Auschill, A Jäger, HJ Knölker

Index: Knott, Kerstin E.; Auschill, Stefan; Jaeger, Anne; Knoelker, Hans-Joachim Chemical Communications, 2009 , # 12 p. 1467 - 1469

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Citation Number: 32

Abstract

Currently, carbazoles are of high interest due to their pharmacological potential. 1 In 1990, Seto et al. at the University of Tokyo isolated the antiostatins A 1 to A 4 and B 2 to B 5 from Streptomyces cyaneus 2007-SV 1 (Fig. 1). 2 They exhibit a strong inhibitory activity against free radical induced lipid peroxidation. The antiostatins are structurally unique because of their nitrogen substituent at C-4, which is part of an isobutylbiuret side chain for the antiostatins B. So far, no ...