Tetrahedron: Asymmetry

Catalytic enantioselective synthesis of the dopamine D1 antagonist ecopipam

S Hajra, S Bar

Index: Hajra, Saumen; Bar, Sukanta Tetrahedron Asymmetry, 2012 , vol. 23, # 2 p. 151 - 156

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Citation Number: 4

Abstract

A concise asymmetric synthesis of the potent dopamine D1 antagonist, ecopipam, has been accomplished in six steps with 33% overall yield via catalytic enantioselective aziridination and subsequent one-pot Friedel–Crafts cyclization of an in situ generated tethered aziridine