(R)-and (S)-3-hydroxy-4, 4-dimethyl-1-phenyl-2-pyrrolidinone by lipase-catalyzed resolution of the racemic mixture: New chiral auxiliaries related to pantolactone
P Camps, S Giménez, M Font-Bardia, X Solans
Index: Camps; Gimenez; Font-Bardia; Solans Tetrahedron Asymmetry, 1995 , vol. 6, # 4 p. 985 - 990
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Citation Number: 27
Abstract
(R)-and (S)-3-Hydroxy-4, 4-dimethyl-1-phenyl-2-pyrrolidinone (R)-and (S)-1 have been prepared by lipase-catalyzed enantioselective acetylation of (S)-1 from rac-1 with vinyl acetate. Controlled hydrolysis of the acetate (S)-2 gave (S)-1. The configuration of (R)-1 and its p-bromobenzoate (R)-3 were established by X-ray diffraction analysis.
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