Structural and stereochemical requirements of the spiroketal group of hippuristanol for antiproliferative activity
W Li, Y Dang, JO Liu, B Yu
Index: Li, Wei; Dang, Yongjun; Liu, Jun O.; Yu, Biao Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 10 p. 3112 - 3115
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Citation Number: 10
Abstract
Hippuristanol is a natural product that has recently been shown to inhibit eukaryotic translation initiation and tumor cell proliferation. To investigate the structure and activity relationship of hippuristanol, we synthesized a series of analogs by expanding the size of its F ring and determined their effects on the proliferation of cancer cell lines. All changes to the F-ring of hippuristanol resulted in 3-fold to> 100-fold decrease in activity.
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