Tetrahedron: Asymmetry

Determination of energy barriers and racemization mechanisms for thermally interconvertable barbituric and thiobarbituric acid enantiomers

SF Oğuz, İ Doğan

Index: Oguz, S. Funda; Dogan, Ilknur Tetrahedron Asymmetry, 2003 , vol. 14, # 13 p. 1857 - 1864

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Citation Number: 14

Abstract

The enantiomers of the 5, 5-dimethyl-1-(o-aryl) barbituric and 2-thiobarbituric acid derivatives have been separated by micropreparative liquid chromatography on the Chiralcel OD-H column. The activation barriers for the conversion of one enantiomer to its counterpart (M⇄ P) have been determined upon thermal racemization of the separated enantiomers by following the intensity changes in the HPLC chromatograms with time. ...