Synthesis of ranolazine metabolites and their anti-myocardial ischemia activities

Z Yao, S Gong, T Guan, Y Li, X Wu, H Sun

Index: Yao, Zhangyu; Gong, Shubo; Guan, Teng; Li, Yunman; Wu, Xiaoming; Sun, Hongbin Chemical and Pharmaceutical Bulletin, 2009 , vol. 57, # 11 p. 1218 - 1222

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Citation Number: 7

Abstract

The anti-anginal drug Ranolazine, a partial fatty acid oxidation (pFOX) inhibitor, is thought to modulate the metabolism during myocardial ischemia by activating pyruvate dehydrogenase activity to promote glucose oxidation. Ranolazine and its five principal metabolites: CVT- 2512, CVT-2513, CVT-2514, CVT-2738 and CVT-4786, were synthesized. The effect of Ranolazine and its metabolites on the ECG (electrocardiogram) of mice with myocardial ...