Journal of heterocyclic chemistry

Synthesis of 4, 7??disubstituted spirobenzofuran??2 (3H)??cyclohexanes

BJ Bradbury, RD Sindelar

Index: Bradbury, Barton J.; Sindelar, Robert D. Journal of Heterocyclic Chemistry, 1989 , vol. 26, p. 1827 - 1833

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Citation Number: 6

Abstract

Abstract A general synthetic strategy was designed for the preparation of 7-substituted-4- methoxy-and 4-hydroxyspiro [benzofuran-2 (3H)-cyclohexanes] 5 and 6 (Figure 1) using successive, regioselective hetero-atom-facilitated aromatic lithiation reactions and subsequent reaction with various electrophiles.

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