Tyrosine kinase inhibitors. 3. Structure-activity relationships for inhibition of protein tyrosine kinases by nuclear-substituted derivatives of 2, 2'-dithiobis (1-methyl-N- …

GW Rewcastle, BD Palmer, EM Dobrusin…

Index: Rewcastle; Palmer; Dobrusin; Fry; Kraker; Denny Journal of Medicinal Chemistry, 1994 , vol. 37, # 13 p. 2033 - 2042

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Citation Number: 30

Abstract

A series of indole-substituted 2, 2'-dithiobis (l-methyl-N-phenyl-1H-indole-3-carboxamides) were prepared and evaluated for their ability to inhibit the tyrosine kinase activity of both the epidermal growth factor receptor (EGFR) and the nonreceptor ppG0V-B" tyrosine kinase. The compounds were synthesized by conversion of appropriate 1-methyloxindoles to 1- methyl-Zindolinethiones with P2s5 followed by subsequent reaction with NaH and phenyl ...