Tetrahedron letters

Synthesis of heterocyclic β-amino acids. A convenient preparation of β-amino-5-pyrimidinepropanoic acid and derivatives.

PR Bovy, JG Rico

Index: Bovy, Philippe R.; Rico, Joseph G. Tetrahedron Letters, 1993 , vol. 34, # 50 p. 8015 - 8018

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Citation Number: 12

Abstract

The novel (2E)-1,1-dimethylethyl-3-(5-pyrimidinyl)-2-propenoate , obtained by Heck coupling between 5-bromopyrimidine and tert-butyl acrylate undergoes nearly quantitative Michael addition in t-butanol saturated with ammonia to the hitherto unknown ...