A highly facile approach to the synthesis of novel 2-(3-benzyl-2, 4-dioxo-1, 2, 3, 4-tetrahydropyrimidin-1-yl)-N-phenylacetamides

…, AO Chizhov, AL Khandazhinskaya, KL Seley-Radtke

Index: Novikov, Mikhail S.; Babkov, Denis A.; Paramonova, Maria P.; Chizhov, Alexander O.; Khandazhinskaya, Anastasia L.; Seley-Radtke, Katherine L. Tetrahedron Letters, 2013 , vol. 54, # 6 p. 576 - 578

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Citation Number: 6

Abstract

A series of heterocyclic compounds were designed as potential nonnucleoside HIV reverse transcriptase inhibitors. Although the compounds ultimately proved inactive against HIV, during the course of the synthesis, a new and highly facile method to realize N- phenylacetamides was developed. Notably, the new route avoids the intractable workups and byproducts previously reported procedures have been associated with, thereby ...