An Improved Process for the N??Demethylation of Opiate Alkaloids using an Iron (II) Catalyst in Acetate Buffer

G Kok, TD Ashton, PJ Scammells

Index: Kok, Gaik; Ashton, Trent D.; Scammellsa, Peter J. Advanced Synthesis and Catalysis, 2009 , vol. 351, # 1-2 p. 283 - 286

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Citation Number: 22

Abstract

Abstract An improved process to N-demethylate opiate alkaloids utilising a solution of the ferrous porphyrin, tetrasodium 5, 10, 15, 20-tetra (4-sulfophenyl) porphyrinatoiron (II)[= Fe (II)- TPPS (8)], in acetate buffer is described. This method provided the corresponding N- demethylated opiates in good yield with high reproducibility.