European journal of medicinal chemistry

8-Aryl-and alkyloxycaffeine analogues as inhibitors of monoamine oxidase

B Strydom, JJ Bergh, JP Petzer

Index: Strydom, Belinda; Bergh, Jacobus J.; Petzer, Jacobus P. European Journal of Medicinal Chemistry, 2011 , vol. 46, # 8 p. 3474 - 3485

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Citation Number: 20

Abstract

Abstract Recently it was reported that a series of 8-benzyloxycaffeine analogues are potent reversible inhibitors of human monoamine oxidase (MAO) A and B. In an attempt to discover additional C8 oxy substituents of caffeine that lead to potent MAO inhibition, a series of related 8-aryl-and alkyloxycaffeine analogues were synthesized and their MAO-A and-B inhibition potencies were compared to those of the 8-benzyloxycaffeines. The results ...