Studies on diastereoselective reduction of cyclic β-ketoesters with boron hydrides. Part 4: The reductive profile of functionalized cyclohexanone derivatives

…, CMR Sant'Anna, KV Maria da Conceiçao…

Index: Fraga, Carlos A.M.; Teixeira, Lis Helena P.; Menezes, Carla Maria De S.; Sant'Anna, Carlos Mauricio R.; Ramos, Maria Da Conceicao K.V.; De Aquino Neto, Francisco R.; Barreiro, Eliezer J. Tetrahedron, 2004 , vol. 60, # 12 p. 2745 - 2755

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Citation Number: 2

Abstract

Reduction of 2-allyl-2-carboalkoxycyclohexanones (), 2-propyl-2- carboethoxycyclohexanone () and 2-benzyl-2-carboethoxycyclohexanone () with boron hydrides in the presence and absence of several chelating agents were studied. Molecular modeling studies using semiempirical PM3 method were performed in order to find a suitable explanation of the diastereoselection of ketone carbonyl faces during the ...