Tetrahedron letters

A Convenient synthesis of the, conformationally constrained amino acid 5, 5-dimethylproline

VW Magaard, RM Sanchez, JW Bean, ML Moore

Index: Magaard, Victoria W.; Sanchez, Robert M.; Bean, John W.; Moore, Michael L. Tetrahedron Letters, 1993 , vol. 34, # 3 p. 381 - 384

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Citation Number: 68

Abstract

Abstract A convenient synthesis of Boc-DL-5, 5-dimethylproline methyl ester is described. This conformationally-constrained amino acid may be expected to exist predominantly in the cis peptide bond isomer when into peptides. The peptide bond in the model peptide Boc- Phe-Me 2 Pro-OMe is shown to be 90% in the cis isomer.