Improved protection and esterification of a precursor of the taxotere® and taxol side chains
A Commerçon, D Bézard, F Bernard, JD Bourzat
Index: Commercon; Bezard; Bernard; Bourzat Tetrahedron Letters, 1992 , vol. 33, # 36 p. 5185 - 5188
Full Text: HTML
Citation Number: 142
Abstract
Abstract (4S, 5R)-N-BOC-2, 2-dimethyl-4-phenyl-5-oxazolidinecarboxylic acid 8 was prepared and efficiently esterified by conveniently protected baccatins 9a, b. Smooth deprotection in formic acid gave the N-deprotected intermediates of Taxotere® and taxol. This protocol did not generate any epimerization at C-2′ and constitutes a pratical method to prepare Taxotere®, taxol and analogs.
Related Articles:
[Nandanan; Phukan, Prodeep; Sudalai Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1999 , vol. 38, # 3 p. 283 - 286]
[Nandanan; Phukan, Prodeep; Sudalai Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1999 , vol. 38, # 3 p. 283 - 286]
Chemo-enzymatic synthesis of all isomeric 3-phenylserines and-isoserines
[Hoenig, H.; Seufer-Wasserthal, P.; Weber, H. Tetrahedron, 1990 , vol. 46, # 11 p. 3841 - 3850]
[Nandanan; Phukan, Prodeep; Sudalai Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1999 , vol. 38, # 3 p. 283 - 286]
[Nandanan; Phukan, Prodeep; Sudalai Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1999 , vol. 38, # 3 p. 283 - 286]