Carbamates of 4′-demethyl-4-deoxypodophyllotoxin: Synthesis, cytotoxicity and cell cycle effects

…, NN Zhou, J Liu, WT Huang, L Hui, Y Jin, YX Jin

Index: Chen, Shi-Wu; Gao, Yuan-Yu; Zhou, Ni-Ni; Liu, Jie; Huang, Wen-Ting; Hui, Ling; Jin, Yan; Jin, Yong-Xin Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 24 p. 7355 - 7358

Full Text: HTML

Citation Number: 15

Abstract

In an attempt to generate compounds with superior bioactivity and reduced toxicity, 12 carbamates of 4′-demethyl-4-deoxypodophyllotoxin, N-(1-oxyl-4′-demethyl-4- deoxypodophyllic)-α-amino acids amides, were synthesized and evaluated for antiproliferative activity and cell cycle effects. These synthesized compounds proved to be more hydrophilic, as well as improved or comparable in vitro cytotoxicities against four cell ...