Synthesis and octopaminergic agonist activity of 2-(substituted benzylamino)-2-thiazolines

A Hirashima, Y Yoshii, M Eto

Index: Hirashima, Akinori; Yoshii, Yutaka; Eto, Morifusa Bioscience, Biotechnology, and Biochemistry, 1992 , vol. 56, # 7 p. 1062 - 1065

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Citation Number: 21

Abstract

2-(Substituted benzylamino)-2-thiazolines (SBAT) were synthesized by a hydrochloric acid- catalyzed cyclization of the corresponding thioureas, using a reaction of 2-methylthio-2- thiazoline with substituted benzylamines or by alkylating 2-amino-2-thiazoline. 2-(Alkylthio)- 2-thiazolines were obtained by alkylating 2-mercaptothiazoline. Most of the SBAT compounds activated adenylate cyclase in homogenates of cockroach ventral nerve cords ...