One-Pot and Regiospecific Synthesis of 2, 3-Disubstituted Indoles from 2-Bromoanilides via Consecutive Palladium-Catalyzed Sonogashira Coupling, …
…, HX Wei, Y Zhang, W Zhao, M Dufour, G Li…
Index: Lu, Bruce Z.; Wei, Han-Xun; Zhang, Yongda; Zhao, Wenyi; Dufour, Marine; Li, Guisheng; Farina, Vittorio; Senanayake, Chris H. Journal of Organic Chemistry, 2013 , vol. 78, # 9 p. 4558 - 4562
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Citation Number: 28
Abstract
The indole motif is a ubiquitous feature of alkaloid natural products and represents a privileged structural element for pharmaceutically active compounds.(1) Despite the plethora of methodologies developed for synthesis of this heterocyclic system,(2) efficient general methods for regioselective preparation of highly substituted indoles are limited.(3) As a program of developing practical and economical processes, we have reported several efficient methods for the ...
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