Syntheses of deuterium labeled prenyldiphosphate and prenylcysteine analogues for in vivo mass spectrometric quantification

T Subramanian, KL Subramanian…

Index: Subramanian, Thangaiah; Subramanian, Karunai Leela; Sunkara, Manjula; Onono, Fredrick O.; Morris, Andrew J.; Spielmann, H. Peter Journal of Labelled Compounds and Radiopharmaceuticals, 2013 , vol. 56, # 8 p. 370 - 375

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Citation Number: 3

Abstract

A Wittig reaction employing Li (CD3) 2CP (C6H5) 3 was used to prepare d6-farnesol and d6- geranylgeraniol. Reductive amination of aniline-2, 3, 4, 5, 6-d5 was used to prepare the unnatural isoprenoid analogues d5-anilinogeraniol and d5-anilinofarnesol. All of these deuterated isoprenols were elaborated into their diphosphate and cysteine thioether derivatives suitable for use as stable-isotope labeled standards for quantitative mass ...