Synthesis of some new 2, 4-disubstituted thiazoles as possible antibacterial and anti-inflammatory agents

…, KV Malini, BS Rao, BK Sarojini, NS Kumari

Index: Holla, B. Shivarama; Malini; Rao, B. Sooryanarayana; Sarojini; Kumari, N. Suchetha European Journal of Medicinal Chemistry, 2003 , vol. 38, # 3 p. 313 - 318

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Citation Number: 254

Abstract

A series of arylthioureas (1), aromatic aldehyde thiosemicarbazones (2) and 5-aryl-2- furfuraldehyde thiosemicarbazones (3) were condensed with 2, 4-dichloro-5-fluorophenacyl bromide to yield respective arylaminothiazoles, arylidene/5-aryl-2-furfurylidene hydrazinothiazoles (4). The newly synthesized compounds were characterized by IR, 1H- NMR and mass spectral studies. These compounds were also screened for their ...