Catalytic and regioselective acylation of aromatic heterocycles using carbon monoxide and olefins

…, TJ O'Connell, J Harris, L LaBounty…

Index: Moore, Eric J.; Pretzer, Wayne R.; O'Connell, Todd J.; Harris, Johnel; Labounty, Leslie; Chou, Loretta; Scott Grimmer Journal of the American Chemical Society, 1992 , vol. 114, # 14 p. 5888 - 5890

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Citation Number: 202

Abstract

The kinetics of the acylation reaction has been examined in some detail. The reaction exhibits first-order rate kinetics with respect to pyridine and RU,(CO)~~ and is zero order in CO pressure (50-500 psi) and olefin concentration." Good first-order rate plots were obtained, affording a pseudo-first-order rate constant of 2.6 X sI. A possible mechanism for formation of 2 and 3 involves nucleophilic attack of pyridine on a coordinatively ...