Catalytic scaffolding ligands: an efficient strategy for directing reactions

TE Lightburn, MT Dombrowski…

Index: Lightburn, Thomas E.; Dombrowski, Michael T.; Tan, Kian L. Journal of the American Chemical Society, 2008 , vol. 130, # 29 p. 9210 - 9211

Full Text: HTML

Citation Number: 88

Abstract

The design and application of a scaffolding ligand that promotes branch and diastereoselective hydroformylation of terminal olefins as well as the regio-and diastereoselective hydroformylation of disubstituted olefins is reported. It is shown that the ligand covalently and reversibly bonds to the substrate, allowing for directed hydroformylation. As the substrate ligand interaction is dynamic, hydroformylations are ...