Facile Synthesis of Lipophilic δ-Amino Acid Conjugates from 4-Alkoxy-dithionaphthoic Acids

…, CE Needham, DB Franklin, AJ Lampkins

Index: Worth, Anna C.; Needham, Catherine E.; Franklin, Donald B.; Lampkins, Andrew J. Synthetic Communications, 2012 , vol. 42, # 18 p. 2694 - 2706

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Abstract

The design of drug molecules and medicinal peptides whose biological target(s) lie within the central nervous system (CNS) poses a unique set of bioavailability challenges. [ 1 1. Su , Y. ; Sinko , PJ Drug delivery across the blood–brain barrier: Why is it difficult? How to measure and improve it? Expert Opin. Drug Deliv. 2006 , 3 , 419 – 435 . [Taylor & Francis Online], [PubMed], [Web of Science ®] View all references ] Unless directly administered (ie, ...