Enantioselective Titanium (III)??Catalyzed Reductive Cyclization of Ketonitriles

J Streuff, M Feurer, P Bichovski, G Frey…

Index: Streuff, Jan; Feurer, Markus; Bichovski, Plamen; Frey, Georg; Gellrich, Urs Angewandte Chemie - International Edition, 2012 , vol. 51, # 34 p. 8661 - 8664

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Citation Number: 42

Abstract

Samarium (II)-mediated reductive cyclizations are standard tools in organic chemistry and have found broad application in the synthesis of natural products and drugs.[1] Of these reactions, the reductive cyclization of w-ketonitriles [2] is of particular interest because the resulting a-hydroxyketone (acyloin) fragment is present in over 1500 known natural products. Examples include barbacenic acid, cortistatinD, dragmacidin F, sieboldine A, ...