Scaffold hopping strategy toward original pyrazolines as selective CB 2 receptor ligands

…, R Mansouri, P Chavatte, V Levacher, JF Brière

Index: Gembus, Vincent; Furman, Christophe; Millet, Regis; Mansouri, Roxane; Chavatte, Philippe; Levacher, Vincent; Briere, Jean-Francois European Journal of Medicinal Chemistry, 2012 , vol. 58, p. 396 - 404

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Citation Number: 7

Abstract

In line of a scaffold hopping strategy of pyrazole structures, especially known as potent CB2 receptor antagonists, we exploited an original and convergent synthesis of a new class of C4-benzyl pyrazolines and derivatives from readily available hydrazones and enones (two or three steps). Making use of a mixture of resin supported reagents strategy an efficient domino process allowed the easy construction of various dihydropyrazoles in 63–83% ...