A one-pot alkylation of aromatic aldehydes
DL Comins, JD Brown, NB Mantlo
Index: Comins, Daniel L.; Brown, Jack D.; Mantlo, Nathan B. Tetrahedron Letters, 1982 , vol. 23, # 39 p. 3979 - 3982
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Citation Number: 73
Abstract
Download full text in PDF Opens in a new window. Article suggestions will be shown in a dialog on return to ScienceDirect. ... Please enable JavaScript to use all the features on this page. ... The addition of aromatic aldehydes to lithium N-methylpiperazide in benzene gave α-amino alkoxides which were ortho-lithiated with excess -butyllithium. Subsequent alkylation and hydrolysis provided ortho-substituted aromatic aldehydes via a one-pot reaction.
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