Chemistry Letters

Asymmetric reductions with freely and non-freely rotating amide group NADH models.

…, P Binay, G Dupas, J Bourguignon, G Queguiner

Index: Combret, Yves; Torche, Jean Jacques; Binay, Patrice; Dupas, Georges; Bourguignon, Jean; Queguiner, Guy Chemistry Letters, 1991 , # 1 p. 125 - 128

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Citation Number: 15

Abstract

NADH models with a freely or non freely rotating chiral amide group have been synthesized and used in the reduction of methyl benzoylformate. The same major enantiomer was obtained in all cases. A blocked reagent bearing a phenylalaninol group as chiral auxiliary allows one to obtain a high ee