Synthesis and antidepressant activity of 5-(1-aryl-4-piperazino) methyl-2-amino-2-oxazolines

…, C Jarry, A Carpy, E Panconi, P Descas

Index: Bosc; Jarry; Carpy; Panconi; Descas European Journal of Medicinal Chemistry, 1992 , vol. 27, # 5 p. 437 - 442

Full Text: HTML

Citation Number: 25

Abstract

Abstract The synthesis of 20 5-(1-aryl-4-piperazino) methyl-2-amino-2-oxazolines is described. Antidepressant activity was observed in mice using classical screening tests. Structure-activity relationships were studied and correlated with the nature of the aromatic substituent. Preliminary lipophilic and electronic properties of one lead compound (COR 3224) have been described.