Azide solid phase peptide synthesis

AM Felix, RB Merrifield

Index: Felix,A.M.; Merrifield,R.B. Journal of the American Chemical Society, 1970 , vol. 92, p. 1385 - 1391

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Citation Number: 63

Abstract

Abstract: The stepwise synthesis of peptides by the initial attachment of an amino acid r- butyloxycarbonylhydrazide through its a-amino group to a polystyrene resin was investigated. The resin-amino acid azide was generated quantitatively and coupled with another amino acid t-butyloxycarbonylhydrazide. The peptide chain was elongated by further azige couplings. Finally, the C-terminal amino acid was added as a t-butyl ester. ...