Benzotriazole-assisted synthesis of monoacyl aminals and their peptide derivatives

AR Katritzky, L Urogdi, A Mayence

Index: Katritzky, Alan R.; Urogdi, Laszlo; Mayence, Annie Journal of Organic Chemistry, 1990 , vol. 55, # 4 p. 2206 - 2214

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Citation Number: 58

Abstract

Reversing one or more of the amide groups (ie CHRCONH to CHRNHCO) of a linear peptide gives a so-called" partially modified retro isomer" and represents an important strategy in peptide analogue research.'" Y2 The modified sequence requires both a malonic unit and a (much less easily available) a, a-diamino moiety. Such a, a-diamino units have been synthesized by C urti~ s-'~~~~ or H~ ffmann-type~*~ p~ rearrangements of protected ...