Tetrahedron

3-Thiolated 2-azetidinones: synthesis and in vitro antibacterial and antifungal activities

M Zarei, M Mohamadzadeh

Index: Zarei, Maaroof; Mohamadzadeh, Masoud Tetrahedron, 2011 , vol. 67, # 32 p. 5832 - 5840

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Citation Number: 40

Abstract

Abstract A series of 3-thiolated β-lactams were synthesized by [2+ 2] ketene–imine cycloaddition reaction from S-substituted mercaptoacetic acids and Schiff bases. Then, some of the 3-methylthio β-lactams were converted to 3-(methylsulfinyl) β-lactams and 3- (methylsulfonyl) β-lactams using m-CPBA under different reaction conditions. All the compounds were characterized by spectral data and elemental analyses and were ...