Rational design and synthesis of thioridazine analogues as enhancers of the antituberculosis therapy

M Pieroni, D Machado, E Azzali…

Index: Kigondu, Elizabeth M.; Njoroge, Mathew; Singh, Kawaljit; Njuguna, Nicholas; Warner, Digby F.; Chibale, Kelly MedChemComm, 2014 , vol. 5, # 4 p. 502 - 506

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Citation Number: 10

Abstract

... Volume: Page ... basic amino groups (TZ, VP, reserpine), which likely occur to be protonated at the acidic pH of the sites infected by M. tuberculosis ... reflux, 18h, 50%; (d) isopropyl bromide, NaH, DMF, rt, 18 h, 47%; (e) NaH, DMF, reflux, 18–72 h, 9–70%; (f) NaNH 2 ...