Journal of medicinal chemistry

5-Piperazinylalkyl-2 (3H)-oxazolones with neuroleptic activity

G Cascio, E Manghisi, G Fregnan

Index: Cascio, Giuseppe; Manghisi, Elso; Fregnan, Giancarlo Journal of Medicinal Chemistry, 1989 , vol. 32, # 10 p. 2241 - 2247

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Citation Number: 13

Abstract

2 (3H)-Oxazolones have received little attention as molecules of potential pharmacological interest; however, sedative and muscle relaxant activity were found to be associated with some 4-aryl-2 (3H)-oxazolones.'As part of a program aimed at discovering new series of therapeutically active compounds, a number of 4-aryl-2 (3H)-oxazolones bearing an aminoethyl group in the 5-position have been synthesized in our laboratories; ...